Marked by the beginning and end of the war in Afghanistan, the strategic presence of China, Russia and the United States in Central Asia has undergone major changes. The U.S. strategic presence in the region slides from peak to trough, while the strategic presence of China and Russia continues to rise. The article selects the three perspectives of military security, economy and energy, people-to-people ties and national image, analyzes the status and changes of the three countries in the three fields, and compares their strengths and weaknesses.