For the past 13 years, the war in Afghanistan has dominated U.S. Central Asia policy. After withdrawing from Afghanistan, the structure of U.S.-Central Asia interests will change, and the war in Afghanistan will no longer be the dominant factor of U.S.- Central Asia policy, which will lead to policy adaptation. The status of Central Asia in U.S. diplomacy will decline, and the U.S. will pay less attention to the region. The influence of Russia and China will rise, geopolitics will return to the center of America’s Central Asia policy, and the balance of power between the great powers will take on a new shape. The United States will continue to promote the “New Silk Road Strategy” and continue to participate in the “great game” in Central Asia, but whether it will take Russia or China as its main opponent, there are different judgments.