It was long believed in Western scholarship that the post-Karimov transition may lead to the destabilization of Central Asia. But to their surprise, the transition has proven remarkably stable. In the domestic context, opposition is weak, there are no large-scale interest groups, and Karimov’s excellent ethnic and factional balance made it difficult to form a political force challenging the elite. On the external front, Karimov pursues an equidistant multi-balanced diplomacy that is not too close to the great powers, making it difficult for foreign forces to interfere in Uzbekistan’s internal affairs during the process of political transition. The smooth transition of the Uzbekistan regime has safeguarded the political stability of the region. It has far-reaching significance for the construction of the “Belt and Road” and the deepening of the development of the SCO.